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Circ Res DOI:10.1161/CIRCRESAHA.120.315898

Metabolomics and Proteomics in Type 2 Diabetes.

Publication TypeJournal Article
Year of Publication2020
AuthorsChen, Z-Z, Gerszten, RE
JournalCirc Res
Volume126
Issue11
Pages1613-1627
Date Published2020 May 22
ISSN1524-4571
Abstract

The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the accompanying rise of its complications, including cardiovascular disease, necessitates our understanding of the metabolic disturbances that cause diabetes mellitus. Metabolomics and proteomics, facilitated by recent advances in high-throughput technologies, have given us unprecedented insight into circulating biomarkers of T2D even over a decade before overt disease. These markers may be effective tools for diabetes mellitus screening, diagnosis, and prognosis. As participants of metabolic pathways, metabolite and protein markers may also highlight pathways involved in T2D development. The integration of metabolomics and proteomics with genomics in multiomics strategies provides an analytical method that can begin to decipher causal associations. These methods are not without their limitations; however, with careful study design and sample handling, these methods represent powerful scientific tools that can be leveraged for the study of T2D. In this article, we aim to give a timely overview of circulating metabolomics and proteomics findings with T2D observed in large human population studies to provide the reader with a snapshot into these emerging fields of research.

DOI10.1161/CIRCRESAHA.120.315898
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/32437301?dopt=Abstract

Alternate JournalCirc. Res.
PubMed ID32437301