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Sleep DOI:10.1093/sleep/zsaa099

Narcolepsy Type 1: What have we learned from genetics?

Publication TypeJournal Article
Year of Publication2020
AuthorsOllila, HM
JournalSleep
Date Published2020 May 22
ISSN1550-9109
Abstract

Type-1 narcolepsy is a severe neurological disorder with distinct characteristic of loss of hypocretin neurotransmitter. Genetic analysis in type-1 narcolepsy have revealed a unique signal pointing towards autoimmune, rather than psychiatric origin. While type-1 narcolepsy has been intensively studied the other sub types of hypersomnolence, narcolepsy and hypersomnia are less thoroughly understood. This review summarizes the latest breakthroughs in the field in narcolepsy. The goal of this paper is to help the reader to understand better the risk from genetic factors and their interplay with immune, genetic and epidemiological aspects in narcolepsy.

DOI10.1093/sleep/zsaa099
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/32442260?dopt=Abstract

Alternate JournalSleep
PubMed ID32442260