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Sci Transl Med DOI:10.1126/scitranslmed.aax4517

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.

Publication TypeJournal Article
Year of Publication2020
AuthorsBrook, B, Harbeson, DJ, Shannon, CP, Cai, B, He, D, Ben-Othman, R, Francis, F, Huang, J, Varankovich, N, Liu, A, Bao, W, Bjerregaard-Andersen, M, Schaltz-Buchholzer, F, Sanca, L, Golding, CN, Larsen, KLindberg, Levy, O, Kampmann, B, Tan, R, Charles, A, Wynn, JL, Shann, F, Aaby, P, Benn, CS, Tebbutt, SJ, Kollmann, TR, Amenyogbe, N
Corporate AuthorsEPIC Consortium
JournalSci Transl Med
Date Published2020 May 06

Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration. This was necessary and sufficient to drive emergency granulopoiesis (EG), resulting in a marked increase in neutrophils. This increase in neutrophils was directly and quantitatively responsible for protection from sepsis. Rapid induction of EG after BCG administration also occurred in three independent cohorts of human neonates.


Alternate JournalSci Transl Med
PubMed ID32376769