Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.

Cell Stem Cell
Authors
Keywords
Abstract

Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.

Year of Publication
2014
Journal
Cell Stem Cell
Volume
15
Issue
6
Pages
687-91
Date Published
2014 Dec 04
ISSN
1875-9777
URL
DOI
10.1016/j.stem.2014.10.018
PubMed ID
25479746
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