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J Virol DOI:10.1128/JVI.02752-14

GB virus C coinfections in west African Ebola patients.

Publication TypeJournal Article
Year of Publication2015
AuthorsLauck, M, Bailey, AL, Andersen, KG, Goldberg, TL, Sabeti, PC, O'Connor, DH
JournalJ Virol
Volume89
Issue4
Pages2425-9
Date Published2015 Feb
ISSN1098-5514
KeywordsAdolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Coinfection, Female, Flaviviridae Infections, GB virus C, Hemorrhagic Fever, Ebola, Hepatitis, Viral, Human, Humans, Infant, Infant, Newborn, Male, Middle Aged, Molecular Sequence Data, RNA, Viral, Sequence Analysis, DNA, Sierra Leone, Survival Analysis, Young Adult
Abstract

In 49 patients with known Ebola virus disease outcomes during the ongoing outbreak in Sierra Leone, 13 were coinfected with the immunomodulatory pegivirus GB virus C (GBV-C). Fifty-three percent of these GBV-C(+) patients survived; in contrast, only 22% of GBV-C(-) patients survived. Both survival and GBV-C status were associated with age, with older patients having lower survival rates and intermediate-age patients (21 to 45 years) having the highest rate of GBV-C infection. Understanding the separate and combined effects of GBV-C and age on Ebola virus survival may lead to new treatment and prevention strategies, perhaps through age-related pathways of immune activation.

URLhttp://jvi.asm.org/cgi/pmidlookup?view=long&pmid=25473056
DOI10.1128/JVI.02752-14
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25473056?dopt=Abstract

Alternate JournalJ. Virol.
PubMed ID25473056
PubMed Central IDPMC4338908
Grant ListC06 RR020141 / RR / NCRR NIH HHS / United States
C06 RR015459 / RR / NCRR NIH HHS / United States
P51 RR000167 / RR / NCRR NIH HHS / United States
RR15459-01 / RR / NCRR NIH HHS / United States
T32 GM081061 / GM / NIGMS NIH HHS / United States
RR020141-01 / RR / NCRR NIH HHS / United States
R01 AI077376-01 / AI / NIAID NIH HHS / United States
R01AI077376 / AI / NIAID NIH HHS / United States
R01 AI077376 / AI / NIAID NIH HHS / United States
P51RR000167 / RR / NCRR NIH HHS / United States
T32 GM008692 / GM / NIGMS NIH HHS / United States
T32 AI055397 / AI / NIAID NIH HHS / United States
R01 AI098420 / AI / NIAID NIH HHS / United States