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Nature DOI:10.1038/s41586-020-2025-2

Pathway paradigms revealed from the genetics of inflammatory bowel disease.

Publication TypeJournal Article
Year of Publication2020
AuthorsGraham, DB, Xavier, RJ
JournalNature
Volume578
Issue7796
Pages527-539
Date Published2020 Feb
ISSN1476-4687
Abstract

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and amplified by the confluence of multiple genetic and environmental variables that perturb the immune-microbiome axis. The challenge of dissecting pathological mechanisms underlying IBD has led to the development of transformative approaches in human genetics and functional genomics. Here we describe IBD as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecular pathways that regulate homeostasis of the mucosal immune system. Finally, we synthesize emerging insights from multiple experimental approaches into pathway paradigms and discuss future prospects for disease-subtype classification and therapeutic intervention.

DOI10.1038/s41586-020-2025-2
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/32103191?dopt=Abstract

Alternate JournalNature
PubMed ID32103191