Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Nat Commun

Authors	Sara Willems Daniel Wright Felix Day Katerina Trajanoska Peter Joshi John Morris Amy Matteini Fleur Garton Niels Grarup Nikolay Oskolkov Anbupalam Thalamuthu Massimo Mangino Jun Liu Ayse Demirkan Monkol Lek Liwen Xu Guan Wang Christopher Oldmeadow Kyle Gaulton Luca Lotta Eri Miyamoto-Mikami Manuel Rivas Tom White Po-Ru Loh Mette Aadahl Najaf Amin John Attia Krista Austin Beben Benyamin Søren Brage Yu-Ching Cheng Paweł Cięszczyk Wim Derave Karl-Fredrik Eriksson Nir Eynon Allan Linneberg Alejandro Lucia Myosotis Massidda Braxton Mitchell Motohiko Miyachi Haruka Murakami Sandosh Padmanabhan Ashutosh Pandey Ioannis Papadimitriou Deepak Rajpal Craig Sale Theresia Schnurr Francesco Sessa Nick Shrine Martin Tobin Ian Varley Louise Wain Naomi Wray Cecilia Lindgren Daniel MacArthur Dawn Waterworth Mark McCarthy Oluf Pedersen Kay-Tee Khaw Douglas Kiel GEFOS Any-Type of Fracture Consortium Yannis Pitsiladis Noriyuki Fuku Paul Franks Kathryn North Cornelia van Duijn Karen Mather Torben Hansen Ola Hansson Tim Spector Joanne Murabito J Brent Richards Fernando Rivadeneira Claudia Langenberg John Perry Nick Wareham Robert Scott
Keywords	Female Humans Male Adult Aged Neoplasm Proteins Middle Aged Cohort Studies Genome-Wide Association Study Polymorphism, Single Nucleotide Nuclear Proteins Repressor Proteins European Continental Ancestry Group Membrane Proteins Genetic Loci Genetics, Population Actins United Kingdom Hand Hand Strength Transforming Growth Factor alpha
Abstract	Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P
Year of Publication	2017
Journal	Nat Commun
Volume	8
Pages	16015
Date Published	2017 07 12
ISSN	2041-1723
DOI	10.1038/ncomms16015
PubMed ID	29313844
PubMed Central ID	PMC5510175
Links	DOI Google Scholar PubMed
Grant list	P30 DK048520 / DK / NIDDK NIH HHS / United States MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom G1000143 / MRC_ / Medical Research Council / United Kingdom MC_U106179473 / MRC_ / Medical Research Council / United Kingdom R01 AR041398 / AR / NIAMS NIH HHS / United States MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom P30 DK072488 / DK / NIDDK NIH HHS / United States G0401527 / MRC_ / Medical Research Council / United Kingdom U24 AG051129 / AG / NIA NIH HHS / United States WT_ / Wellcome Trust / United Kingdom R21 AR056405 / AR / NIAMS NIH HHS / United States MC_QA137853 / MRC_ / Medical Research Council / United Kingdom MR/N011317/1 / MRC_ / Medical Research Council / United Kingdom UL1 TR002369 / TR / NCATS NIH HHS / United States MC_UU_12015/3 / MRC_ / Medical Research Council / United Kingdom MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom R01 HL105756 / HL / NHLBI NIH HHS / United States G0902313 / MRC_ / Medical Research Council / United Kingdom U01 HG004436 / HG / NHGRI NIH HHS / United States

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