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Nat Commun DOI:10.1038/s41467-019-13460-3

Genomic and immune profiling of pre-invasive lung adenocarcinoma.

Publication TypeJournal Article
Year of Publication2019
AuthorsChen, H, Carrot-Zhang, J, Zhao, Y, Hu, H, Freeman, SS, Yu, S, Ha, G, Taylor, AM, Berger, AC, Westlake, L, Zheng, Y, Zhang, J, Ramachandran, A, Zheng, Q, Pan, Y, Zheng, D, Zheng, S, Cheng, C, Kuang, M, Zhou, X, Zhang, Y, Li, H, Ye, T, Ma, Y, Gao, Z, Tao, X, Han, H, Shang, J, Yu, Y, Bao, D, Huang, Y, Li, X, Zhang, Y, Xiang, J, Sun, Y, Li, Y, Cherniack, AD, Campbell, JD, Shi, L, Meyerson, M
JournalNat Commun
Volume10
Issue1
Pages5472
Date Published2019 Nov 29
ISSN2041-1723
Abstract

Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in the pre/minimally invasive group. Classes of genome alterations that increase in frequency during the progression to malignancy are revealed. These include mutations in TP53, arm-level copy number alterations, and HLA loss of heterozygosity. Immune infiltration is correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level events and the tumor immune environment.

DOI10.1038/s41467-019-13460-3
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/31784532?dopt=Abstract

Alternate JournalNat Commun
PubMed ID31784532
PubMed Central IDPMC6884501
Grant List81572253 / / National Natural Science Foundation of China (National Science Foundation of China) /
31720103909 / / National Natural Science Foundation of China (National Science Foundation of China) /
31471239 / / National Natural Science Foundation of China (National Science Foundation of China) /
31671368 / / National Natural Science Foundation of China (National Science Foundation of China) /
SHDC12017102 / / Shanghai Shen Kang Hospital Development Center /