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Trends Immunol DOI:10.1016/j.it.2019.05.009

Towards Immunotherapy for Pediatric Brain Tumors.

Publication TypeJournal Article
Year of Publication2019
AuthorsWang, SShiqi, Bandopadhayay, P, Jenkins, MRayna
JournalTrends Immunol
Volume40
Issue8
Pages748-761
Date Published2019 Aug
ISSN1471-4981
Abstract

Pediatric brain tumors are the leading cause of childhood cancer-related death. Immunotherapy is a powerful new approach for treating some refractory cancers; applying this 'fourth pillar' of cancer treatment to pediatric brain tumors is an exciting but challenging prospect. This review offers new perspectives on moving towards successful immunotherapy for pediatric brain tumors, focusing on pediatric high-grade glioma (HGG), a subgroup with universally poor outcomes. We cover chimeric antigen receptor T cell (CAR-T) therapy, vaccine therapy, and checkpoint inhibition in this context, and focus on the need for intimately understanding the growing brain and its immune system. We highlight the challenges associated with the application of immunotherapy in pediatric neuro-oncology, as well as the tissue-specific challenges to be overcome, to achieve improved outcomes.

DOI10.1016/j.it.2019.05.009
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/31229353?dopt=Abstract

Alternate JournalTrends Immunol.
PubMed ID31229353