RNF43 is frequently mutated in colorectal and endometrial cancers.

Nat Genet
Authors
Keywords
Abstract

We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.

Year of Publication
2014
Journal
Nat Genet
Volume
46
Issue
12
Pages
1264-6
Date Published
2014 Dec
ISSN
1546-1718
URL
DOI
10.1038/ng.3127
PubMed ID
25344691
PubMed Central ID
PMC4283570
Links
Grant list
P01CA87969 / CA / NCI NIH HHS / United States
R01 CA118553 / CA / NCI NIH HHS / United States
U54 HG003067 / HG / NHGRI NIH HHS / United States
P01 CA087969 / CA / NCI NIH HHS / United States
R01 CA151993 / CA / NCI NIH HHS / United States
R01CA118553 / CA / NCI NIH HHS / United States
U54HG003067 / HG / NHGRI NIH HHS / United States
UM1CA167552 / CA / NCI NIH HHS / United States
T32 GM007753 / GM / NIGMS NIH HHS / United States
P50CA127003 / CA / NCI NIH HHS / United States
U01 CA176058 / CA / NCI NIH HHS / United States
R01CA168141 / CA / NCI NIH HHS / United States
K07CA190673 / CA / NCI NIH HHS / United States
R01CA151993 / CA / NCI NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
T32GM007753 / GM / NIGMS NIH HHS / United States
P50 CA127003 / CA / NCI NIH HHS / United States
K07 CA190673 / CA / NCI NIH HHS / United States