Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.

J Virol
Authors
Keywords
Abstract

Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.

Year of Publication
2015
Journal
J Virol
Volume
89
Issue
1
Pages
857-62
Date Published
2015 Jan
ISSN
1098-5514
URL
DOI
10.1128/JVI.02328-14
PubMed ID
25320321
PubMed Central ID
PMC4301141
Links
Grant list
DK 63865 / DK / NIDDK NIH HHS / United States
DK 63821 / DK / NIDDK NIH HHS / United States
P01CA050661 / CA / NCI NIH HHS / United States
5T32AI007245 / AI / NIAID NIH HHS / United States
DK 63863 / DK / NIDDK NIH HHS / United States
U01 DK063829 / DK / NIDDK NIH HHS / United States
UC4 DK095300 / DK / NIDDK NIH HHS / United States
DK 63829 / DK / NIDDK NIH HHS / United States
T32 AI007245 / AI / NIAID NIH HHS / United States
UC4 DK063829 / DK / NIDDK NIH HHS / United States
R01CA63113 / CA / NCI NIH HHS / United States
UC4DK095300 / DK / NIDDK NIH HHS / United States
HHSN267200700014C / DK / NIDDK NIH HHS / United States
R0137667 / PHS HHS / United States
DK 63790 / DK / NIDDK NIH HHS / United States
F31 CA177274 / CA / NCI NIH HHS / United States
DK 63836 / DK / NIDDK NIH HHS / United States
R01CA93804 / CA / NCI NIH HHS / United States
R01 CA093804 / CA / NCI NIH HHS / United States
DK 63861 / DK / NIDDK NIH HHS / United States
R01 CA037667 / CA / NCI NIH HHS / United States
F31CA177274 / CA / NCI NIH HHS / United States
HHSN267200700014C / PHS HHS / United States
P01 CA050661 / CA / NCI NIH HHS / United States
R01 CA063113 / CA / NCI NIH HHS / United States