Mechanisms and function of autophagy in intestinal disease.
Autophagy
Authors | |
Keywords | |
Abstract | The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights recent work on the functional characterization of IBD-associated human genetic variants in cell type-specific functions for autophagy. |
Year of Publication | 2018
|
Journal | Autophagy
|
Volume | 14
|
Issue | 2
|
Pages | 216-220
|
Date Published | 2018
|
ISSN | 1554-8635
|
DOI | 10.1080/15548627.2017.1389358
|
PubMed ID | 29130415
|
PubMed Central ID | PMC5902220
|
Links | |
Grant list | U19 AI109725 / AI / NIAID NIH HHS / United States
|