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Science DOI:10.1126/science.1247391

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Publication TypeJournal Article
Year of Publication2014
AuthorsFox, IJ, Daley, GQ, Goldman, SA, Huard, J, Kamp, TJ, Trucco, M
JournalScience
Volume345
Issue6199
Pages1247391
Date Published2014 Aug 22
ISSN1095-9203
KeywordsCell Differentiation, Cell- and Tissue-Based Therapy, Heart Diseases, Humans, Muscular Diseases, Nervous System Diseases, Pancreatic Diseases, Pluripotent Stem Cells, Regeneration, Regenerative Medicine
Abstract

Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=25146295
DOI10.1126/science.1247391
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25146295?dopt=Abstract

Alternate JournalScience
PubMed ID25146295
PubMed Central IDPMC4329726
Grant ListP01DK096990 / DK / NIDDK NIH HHS / United States
U01HL099773 / HL / NHLBI NIH HHS / United States
1P01AG043376 / AG / NIA NIH HHS / United States
R01 DK099320 / DK / NIDDK NIH HHS / United States
R01 MH104701 / MH / NIMH NIH HHS / United States
R01 NS075345 / NS / NINDS NIH HHS / United States
P01 DK096990 / DK / NIDDK NIH HHS / United States
R01 MH099578 / MH / NIMH NIH HHS / United States
R01DK099320 / DK / NIDDK NIH HHS / United States
R01DK48794 / DK / NIDDK NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
U01 HL099773 / HL / NHLBI NIH HHS / United States
R01 DK048794 / DK / NIDDK NIH HHS / United States
P01 AG043376 / AG / NIA NIH HHS / United States