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Cosi2 : An efficient simulator of exact and approximate coalescent with selection.
|Publication Type||Journal Article|
|Authors||Shlyakhter, I., Sabeti PC, and Schaffner SF|
|Abstract||Efficient simulation of population genetic samples under a given demographic model is a prerequisite for many analyses. Coalescent theory provides an efficient framework for such simulations, but simulating longer regions and higher recombination rates remains challenging. Simulators based on a Markovian approximation to the coalescent scale well, but do not support simulation of selection. Gene conversion is not supported by any published coalescent simulators that support selection.|
|Year of Publication||2014|
|Journal||Bioinformatics (Oxford, England)|
|Date Published (YYYY/MM/DD)||2014/08/22|