Scientific Publications

Cosi2 : An efficient simulator of exact and approximate coalescent with selection.

Publication TypeJournal Article
AuthorsShlyakhter, I., Sabeti PC, and Schaffner SF
AbstractEfficient simulation of population genetic samples under a given demographic model is a prerequisite for many analyses. Coalescent theory provides an efficient framework for such simulations, but simulating longer regions and higher recombination rates remains challenging. Simulators based on a Markovian approximation to the coalescent scale well, but do not support simulation of selection. Gene conversion is not supported by any published coalescent simulators that support selection.
Year of Publication2014
JournalBioinformatics (Oxford, England)
Date Published (YYYY/MM/DD)2014/08/22
ISSN Number1367-4803
DOI10.1093/bioinformatics/btu562
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/25150247?dopt=Abstract