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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/btu562

Cosi2 : An efficient simulator of exact and approximate coalescent with selection.

Publication TypeJournal Article
Year of Publication2014
AuthorsShlyakhter, I, Sabeti, PC, Schaffner, SF
JournalBioinformatics (Oxford, England)
Date Published2014/08/22

Efficient simulation of population genetic samples under a given demographic model is a prerequisite for many analyses. Coalescent theory provides an efficient framework for such simulations, but simulating longer regions and higher recombination rates remains challenging. Simulators based on a Markovian approximation to the coalescent scale well, but do not support simulation of selection. Gene conversion is not supported by any published coalescent simulators that support selection.