|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Shlyakhter, I, Sabeti, PC, Schaffner, SF|
|Journal||Bioinformatics (Oxford, England)|
Efficient simulation of population genetic samples under a given demographic model is a prerequisite for many analyses. Coalescent theory provides an efficient framework for such simulations, but simulating longer regions and higher recombination rates remains challenging. Simulators based on a Markovian approximation to the coalescent scale well, but do not support simulation of selection. Gene conversion is not supported by any published coalescent simulators that support selection.