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BMC cancer DOI:10.1186/1471-2407-14-518

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Publication TypeJournal Article
Year of Publication2014
AuthorsNaba, A, Clauser, KR, Whittaker, CA, Carr, SA, Tanabe, KK, Hynes, RO
JournalBMC cancer
Date Published2014/07/18

Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major component of the tumor microenvironment, is an important contributor to tumor progression. In order to identify candidate biomarkers, we sought to define ECM signatures of metastatic colorectal cancers and their metastases to the liver.