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Bioessays DOI:10.1002/bies.201400077

DNA replication timing: Coordinating genome stability with genome regulation on the X chromosome and beyond.

Publication TypeJournal Article
Year of Publication2014
AuthorsKoren, A
JournalBioessays
Volume36
Issue10
Pages997-1004
Date Published2014 Oct
ISSN1521-1878
KeywordsAnimals, DNA Replication Timing, Epigenesis, Genetic, Gene Expression Regulation, Genomic Instability, Humans, Inheritance Patterns, X Chromosome
Abstract

Recent studies based on next-generation DNA sequencing have revealed that the female inactive X chromosome is replicated in a rapid, unorganized manner, and undergoes increased rates of mutation. These observations link the organization of DNA replication timing to gene regulation on one hand, and to the generation of mutations on the other hand. More generally, the exceptional biology of the inactive X chromosome highlights general principles of genome replication. Cells may control replication timing by a combination of intrinsic replication origin properties, local chromatin states and global levels of replication factors, leading to a functional separation between the activity of genes and their mutation.

URLhttp://dx.doi.org/10.1002/bies.201400077
DOI10.1002/bies.201400077
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25138663?dopt=Abstract

Alternate JournalBioessays
PubMed ID25138663