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Oncoimmunology DOI:10.4161/onci.29311

Personal neoantigen cancer vaccines: The momentum builds.

Publication TypeJournal Article
Year of Publication2014
AuthorsFritsch, EF, Hacohen, N, Wu, CJ
JournalOncoimmunology
Volume3
Pagese29311
Date Published2014/01/01
ISSN2162-4011
Abstract

Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient's tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer. Despite manufacturing complexity, outstanding questions and desired further improvements, neoantigen vaccines are currently undergoing clinical evaluation.

DOI10.4161/onci.29311
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25101225?dopt=Abstract