|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Bejar, R, Stevenson, KE, Caughey, B, R Lindsley, C, Mar, BG, Stojanov, P, Getz, G, Steensma, DP, Ritz, J, Soiffer, R, Antin, JH, Alyea, E, Armand, P, Ho, V, Koreth, J, Neuberg, D, Cutler, CS, Ebert, BL|
|Journal||J Clin Oncol|
|Date Published||2014 Sep 01|
|Keywords||Adult, Aged, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Mutation, Myelodysplastic Syndromes, Prognosis, Transplantation Conditioning, Transplantation, Autologous, Treatment Outcome, Young Adult|
PURPOSE: Recurrently mutated genes in myelodysplastic syndrome (MDS) are pathogenic drivers and powerfully associated with clinical phenotype and prognosis. Whether these types of mutations predict outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) in patients with MDS is not known.
PATIENTS AND METHODS: We used massively parallel sequencing to examine tumor samples collected from 87 patients with MDS before HSCT for coding mutations in 40 recurrently mutated MDS genes.
RESULTS: Mutations were identified in 92% of patients, most frequently in the ASXL1 (29%), TP53 (21%), DNMT3A (18%), and RUNX1 (16%) genes. In univariable analyses, only TP53 mutations were associated with shorter overall (OS; hazard ratio [HR], 3.74; P
CONCLUSION: Mutations in TP53, TET2, or DNMT3A identify patients with MDS with shorter OS after HSCT.
|Alternate Journal||J. Clin. Oncol.|
|PubMed Central ID||PMC4207878|
|Grant List||R01 HL082945 / HL / NHLBI NIH HHS / United States |
T32 CA009172 / CA / NCI NIH HHS / United States
P30 CA023100 / CA / NCI NIH HHS / United States
K08 DK091360 / DK / NIDDK NIH HHS / United States
5K08DK091360 / DK / NIDDK NIH HHS / United States
R01 CA183559 / CA / NCI NIH HHS / United States
R01HL082945 / HL / NHLBI NIH HHS / United States