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Cold Spring Harb Perspect Med DOI:10.1101/cshperspect.a019802

Fungi on the skin: dermatophytes and Malassezia.

Publication TypeJournal Article
Year of Publication2014
AuthorsWhite, TC, Findley, K, Dawson, TL, Scheynius, A, Boekhout, T, Cuomo, CA, Xu, J, Saunders, CW
JournalCold Spring Harb Perspect Med
Date Published2014 Aug 01
KeywordsArthrodermataceae, Dandruff, Dermatitis, Atopic, Dermatitis, Seborrheic, Dermatomycoses, Genome, Fungal, Host-Pathogen Interactions, Humans, Malassezia, Microbiota, Phylogeny, Skin, Tinea Versicolor

Several human skin diseases and disorders are associated with two groups of fungi, the dermatophytes and Malassezia. Although these skin-related problems are not generally life threatening, they are among the most common diseases and disorders of mankind. These fungi are phylogenetically divergent, with the dermatophytes within the Ascomycota and Malassezia within Basidiomycota. Genome analysis indicates that the adaptations to the skin environment are different in these two groups of fungi. Malassezia are dependent on host lipids and secrete lipases and phospholipases that likely release host fatty acids. The dermatophytes encode multiple enzymes with potential roles in modulating host interactions: polyketide synthases, nonribosomal peptide synthetases, LysM, proteases, kinases, and pseudokinases. These two fungal groups have maximized their interactions with the host using two very different mechanisms.


Alternate JournalCold Spring Harb Perspect Med
PubMed ID25085959
PubMed Central IDPMC4109575