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Nat Cell Biol DOI:10.1038/ncb3015

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

Publication TypeJournal Article
Year of Publication2014
AuthorsMcAllister, SS, Weinberg, RA
JournalNat Cell Biol
Volume16
Issue8
Pages717-27
Date Published2014 Aug
ISSN1476-4679
KeywordsAnimals, Bone Marrow, Cell-Derived Microparticles, Cytokines, Disease Progression, Growth Substances, Humans, Models, Biological, Neoplasm Metastasis, Neovascularization, Pathologic, Spleen, Systems Biology, Tumor Microenvironment
Abstract

Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.

URLhttp://dx.doi.org/10.1038/ncb3015
DOI10.1038/ncb3015
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25082194?dopt=Abstract

Alternate JournalNat. Cell Biol.
PubMed ID25082194
Grant ListR01 CA166284 / CA / NCI NIH HHS / United States
P01 CA080111 / CA / NCI NIH HHS / United States
R01 CA078461 / CA / NCI NIH HHS / United States