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Nat Cell Biol DOI:10.1038/ncb3015

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

Publication TypeJournal Article
Year of Publication2014
AuthorsMcAllister, SS, Weinberg, RA
JournalNat Cell Biol
Date Published2014 Aug
KeywordsAnimals, Bone Marrow, Cell-Derived Microparticles, Cytokines, Disease Progression, Growth Substances, Humans, Models, Biological, Neoplasm Metastasis, Neovascularization, Pathologic, Spleen, Systems Biology, Tumor Microenvironment

Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.


Alternate JournalNat. Cell Biol.
PubMed ID25082194
Grant ListR01 CA166284 / CA / NCI NIH HHS / United States
P01 CA080111 / CA / NCI NIH HHS / United States
R01 CA078461 / CA / NCI NIH HHS / United States