The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

Nat Cell Biol
Authors
Keywords
Abstract

Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.

Year of Publication
2014
Journal
Nat Cell Biol
Volume
16
Issue
8
Pages
717-27
Date Published
2014 Aug
ISSN
1476-4679
URL
DOI
10.1038/ncb3015
PubMed ID
25082194
Links
Grant list
R01 CA166284 / CA / NCI NIH HHS / United States
P01 CA080111 / CA / NCI NIH HHS / United States
R01 CA078461 / CA / NCI NIH HHS / United States