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Nature cell biology DOI:10.1038/ncb3015

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

Publication TypeJournal Article
Year of Publication2014
AuthorsMcAllister, SS, Weinberg, RA
JournalNature cell biology
Volume16
Issue8
Pages717-27
Date Published2014/08/01
ISSN1465-7392
Abstract

Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.

URLhttp://dx.doi.org/10.1038/ncb3015
DOI10.1038/ncb3015
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25082194?dopt=Abstract