You are here

Neuron DOI:10.1016/j.neuron.2009.06.003

Tripping the HCN breaker.

Publication TypeJournal Article
Year of Publication2009
AuthorsLipscombe, D, Pan, JQian
JournalNeuron
Volume62
Issue6
Pages747-50
Date Published2009 Jun 25
ISSN1097-4199
KeywordsAnimals, Cyclic Nucleotide-Gated Cation Channels, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Ion Channel Gating, Membrane Proteins, Potassium Channels
Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plasticity and are culprits in aberrant neuronal activity in certain epilepsies. In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin.

DOI10.1016/j.neuron.2009.06.003
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19555642?dopt=Abstract

Alternate JournalNeuron
PubMed ID19555642