Tripping the HCN breaker.

Neuron
Authors
Keywords
Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plasticity and are culprits in aberrant neuronal activity in certain epilepsies. In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin.

Year of Publication
2009
Journal
Neuron
Volume
62
Issue
6
Pages
747-50
Date Published
2009 Jun 25
ISSN
1097-4199
DOI
10.1016/j.neuron.2009.06.003
PubMed ID
19555642
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