A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in Associated With Reduced Energy Expenditure in American Indians.

Diabetes
Authors
Keywords
Abstract

Pima Indians living in Arizona have a high prevalence of obesity, and we have previously shown that a relatively lower energy expenditure (EE) predicts weight and fat mass gain in this population. EE is a familial trait (heritability = 0.52); therefore, in the current study, we aimed to identify genetic variants that affect EE and thereby influence BMI and body fatness in Pima Indians. Genotypic data from 491,265 variants were analyzed for association with resting metabolic rate (RMR) and 24-h EE assessed in a whole-room calorimeter in 507 and 419 Pima Indians, respectively. Variants associated with both measures of EE were analyzed for association with maximum BMI and percent body fat (PFAT) in 5,870 and 912 Pima Indians, respectively. rs11014566 nominally associated with both measures of EE and both measures of adiposity in Pima Indians, where the G allele (frequency: Pima Indians = 0.60, Europeans

Year of Publication
2017
Journal
Diabetes
Volume
66
Issue
8
Pages
2284-2295
Date Published
2017 08
ISSN
1939-327X
DOI
10.2337/db16-1565
PubMed ID
28476931
PubMed Central ID
PMC5521859
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