|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Delahanty, LM, Pan, Q, Jablonski, KA, Aroda, VR, Watson, KE, Bray, GA, Kahn, SE, Florez, JC, Perreault, L, Franks, PW|
|Corporate Authors||Diabetes Prevention Program Research Group|
|Date Published||2014 Oct|
|Keywords||Adult, Blood Glucose, Body Weight, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Incidence, Life Style, Male, Metabolic Diseases, Middle Aged, Prospective Studies, Risk Factors, Weight Loss, Weight Reduction Programs|
OBJECTIVE: This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors.
RESEARCH DESIGN AND METHODS: This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program (DPP) lifestyle intervention arm (n = 1,000) for predictors of incident diabetes and improvement in cardiometabolic risk factors over 2 years.
RESULTS: Although weight loss in the first 6 months was protective of diabetes (hazard ratio [HR] 0.94 per kg, 95% CI 0.90, 0.98; P
CONCLUSIONS: Two-year weight loss was the strongest predictor of reduced diabetes risk and improvements in cardiometabolic traits.
|Alternate Journal||Diabetes Care|
|PubMed Central ID||PMC4170126|
|Grant List||R01 DK072041 / DK / NIDDK NIH HHS / United States |
R01-DK072014 / DK / NIDDK NIH HHS / United States
U01-DK-048489 / DK / NIDDK NIH HHS / United States
U01 DK048489 / DK / NIDDK NIH HHS / United States
R01-DK072041 / DK / NIDDK NIH HHS / United States
P30 DK017047 / DK / NIDDK NIH HHS / United States