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Diabetes Care DOI:10.2337/dc14-0018

Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program.

Publication TypeJournal Article
Year of Publication2014
AuthorsDelahanty, LM, Pan, Q, Jablonski, KA, Aroda, VR, Watson, KE, Bray, GA, Kahn, SE, Florez, JC, Perreault, L, Franks, PW
Corporate AuthorsDiabetes Prevention Program Research Group
JournalDiabetes Care
Volume37
Issue10
Pages2738-45
Date Published2014 Oct
ISSN1935-5548
KeywordsAdult, Blood Glucose, Body Weight, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Incidence, Life Style, Male, Metabolic Diseases, Middle Aged, Prospective Studies, Risk Factors, Weight Loss, Weight Reduction Programs
Abstract

OBJECTIVE: This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors.

RESEARCH DESIGN AND METHODS: This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program (DPP) lifestyle intervention arm (n = 1,000) for predictors of incident diabetes and improvement in cardiometabolic risk factors over 2 years.

RESULTS: Although weight loss in the first 6 months was protective of diabetes (hazard ratio [HR] 0.94 per kg, 95% CI 0.90, 0.98; P

CONCLUSIONS: Two-year weight loss was the strongest predictor of reduced diabetes risk and improvements in cardiometabolic traits.

URLhttp://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=25024396
DOI10.2337/dc14-0018
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25024396?dopt=Abstract

Alternate JournalDiabetes Care
PubMed ID25024396
PubMed Central IDPMC4170126
Grant ListR01 DK072041 / DK / NIDDK NIH HHS / United States
R01-DK072014 / DK / NIDDK NIH HHS / United States
U01-DK-048489 / DK / NIDDK NIH HHS / United States
U01 DK048489 / DK / NIDDK NIH HHS / United States
R01-DK072041 / DK / NIDDK NIH HHS / United States
P30 DK017047 / DK / NIDDK NIH HHS / United States