You are here

Cancer Discov DOI:10.1158/2159-8290.CD-14-0505

SPSB1 may have MET its match during breast cancer recurrence.

Publication TypeJournal Article
Year of Publication2014
AuthorsQin, Y, McAllister, SS
JournalCancer Discov
Volume4
Issue7
Pages760-1
Date Published2014 Jul
ISSN2159-8290
KeywordsAnimals, Breast Neoplasms, Female, Humans, Neoplasm Recurrence, Local, Proto-Oncogene Proteins c-met, Suppressor of Cytokine Signaling Proteins
Abstract

SUMMARY: Disease recurrence is the most common cause of death for patients with breast cancer, yet little is known about the molecular mechanisms underlying this process. Using inducible transgenic mouse model systems, Feng and colleagues identified SPSB1 as a determinant of breast cancer recurrence by virtue of its ability to protect tumor cells from apoptosis through c-MET activation.

URLhttp://cancerdiscovery.aacrjournals.org/cgi/pmidlookup?view=long&pmid=25002612
DOI10.1158/2159-8290.CD-14-0505
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25002612?dopt=Abstract

Alternate JournalCancer Discov
PubMed ID25002612
PubMed Central IDPMC4090600
Grant ListR01 CA166284 / CA / NCI NIH HHS / United States