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PloS one DOI:10.1371/journal.pone.0101082

Rs964184 (APOA5-A4-C3-A1) Is Related to Elevated Plasma Triglyceride Levels, but Not to an Increased Risk for Vascular Events in Patients with Clinically Manifest Vascular Disease.

Publication TypeJournal Article
Year of Publication2014
Authorsvan de Woestijne, AP, van der Graaf, Y, de Bakker, PI, Asselbergs, FW, Spiering, W, Visseren, FL, SMART Study, G
JournalPloS one
Volume9
Issue6
Pagese101082
Date Published2014/01/01
Abstract

Single nucleotide polymorphisms in the APOA5-A4-C3-A1 gene complex are associated with elevated plasma triglycerides and elevated vascular risk in healthy populations. In patients with clinically manifest vascular disease, hypertriglyceridemia and metabolic syndrome are frequently present, but the contribution of these single nucleotide polymorphisms to plasma triglycerides, effect modification by obesity and risk of recurrent vascular events is unknown in these patients.

URLhttp://dx.plos.org/10.1371/journal.pone.0101082
DOI10.1371/journal.pone.0101082
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24979386?dopt=Abstract