|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Libeskind-Hadas, R, Wu, YC, Bansal, MS, Kellis, M|
|Journal||Bioinformatics (Oxford, England)|
Phylogenetic tree reconciliation is a widely used method for reconstructing the evolutionary histories of gene families and species, hosts and parasites and other dependent pairs of entities. Reconciliation is typically performed using maximum parsimony, in which each evolutionary event type is assigned a cost and the objective is to find a reconciliation of minimum total cost. It is generally understood that reconciliations are sensitive to event costs, but little is understood about the relationship between event costs and solutions. Moreover, choosing appropriate event costs is a notoriously difficult problem.