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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/btu289

Pareto-optimal phylogenetic tree reconciliation.

Publication TypeJournal Article
Year of Publication2014
AuthorsLibeskind-Hadas, R, Wu, YC, Bansal, MS, Kellis, M
JournalBioinformatics (Oxford, England)
Volume30
Issue12
Pagesi87-i95
Date Published2014/06/15
ISSN1367-4803
Abstract

Phylogenetic tree reconciliation is a widely used method for reconstructing the evolutionary histories of gene families and species, hosts and parasites and other dependent pairs of entities. Reconciliation is typically performed using maximum parsimony, in which each evolutionary event type is assigned a cost and the objective is to find a reconciliation of minimum total cost. It is generally understood that reconciliations are sensitive to event costs, but little is understood about the relationship between event costs and solutions. Moreover, choosing appropriate event costs is a notoriously difficult problem.

URLhttp://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=24932009
DOI10.1093/bioinformatics/btu289
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24932009?dopt=Abstract