Protein-protein interactions and genetic diseases: The interactome.

Biochim Biophys Acta
Authors
Abstract

Protein-protein interactions mediate essentially all biological processes. Despite the quality of these data being widely questioned a decade ago, the reproducibility of large-scale protein interaction data is now much improved and there is little question that the latest screens are of high quality. Moreover, common data standards and coordinated curation practices between the databases that collect the interactions have made these valuable data available to a wide group of researchers. Here, I will review how protein-protein interactions are measured, collected and quality controlled. I discuss how the architecture of molecular protein networks has informed disease biology, and how these data are now being computationally integrated with the newest genomic technologies, in particular genome-wide association studies and exome-sequencing projects, to improve our understanding of molecular processes perturbed by genetics in human diseases. This article is part of a Special Issue entitled: From Genome to Function.

Year of Publication
2014
Journal
Biochim Biophys Acta
Volume
1842
Issue
10
Pages
1971-1980
Date Published
2014 Oct
ISSN
0006-3002
URL
DOI
10.1016/j.bbadis.2014.05.028
PubMed ID
24892209
PubMed Central ID
PMC4165798
Links
Grant list
P01 HD068250 / HD / NICHD NIH HHS / United States