Genome-scale neurogenetics: methodology and meaning.

Nat Neurosci
Authors
Keywords
Abstract

Genetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.

Year of Publication
2014
Journal
Nat Neurosci
Volume
17
Issue
6
Pages
756-63
Date Published
2014 Jun
ISSN
1546-1726
URL
DOI
10.1038/nn.3716
PubMed ID
24866041
PubMed Central ID
PMC4912829
Links
Grant list
R01 MH097104 / MH / NIMH NIH HHS / United States