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Nat Neurosci DOI:10.1038/nn.3716

Genome-scale neurogenetics: methodology and meaning.

Publication TypeJournal Article
Year of Publication2014
AuthorsMcCarroll, SA, Feng, G, Hyman, SE
JournalNat Neurosci
Volume17
Issue6
Pages756-63
Date Published2014 Jun
ISSN1546-1726
KeywordsAnimals, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Humans, Mental Disorders, Nervous System Diseases, Neurosciences
Abstract

Genetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.

URLhttp://dx.doi.org/10.1038/nn.3716
DOI10.1038/nn.3716
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24866041?dopt=Abstract

Alternate JournalNat. Neurosci.
PubMed ID24866041
PubMed Central IDPMC4912829
Grant ListR01 MH097104 / MH / NIMH NIH HHS / United States