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Stroke DOI:10.1161/STROKEAHA.114.005208

Effect of genetic variants associated with plasma homocysteine levels on stroke risk.

Publication TypeJournal Article
Year of Publication2014
AuthorsCotlarciuc, I, Malik, R, Holliday, EG, Ahmadi, KR, Pare, G, Psaty, BM, Fornage, M, Hasan, N, Rinne, PE, M Ikram, A, Markus, HS, Rosand, J, Mitchell, BD, Kittner, SJ, Meschia, JF, van Meurs, JBJ, Uitterlinden, AG, Worrall, BB, Dichgans, M, Sharma, P
Corporate AuthorsMETASTROKE and the International Stroke Genetics Consortium
JournalStroke
Volume45
Issue7
Pages1920-4
Date Published2014 Jul
ISSN1524-4628
KeywordsBrain Ischemia, Cohort Studies, Europe, Genetic Association Studies, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome, Homocysteine, Humans, Polymorphism, Single Nucleotide, Risk, Stroke
Abstract

BACKGROUND AND PURPOSE: Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes.

METHODS: Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs.

RESULTS: One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P

CONCLUSIONS: This study found several potential associations with IS and its subtypes: an association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS.

URLhttp://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=24846872
DOI10.1161/STROKEAHA.114.005208
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24846872?dopt=Abstract

Alternate JournalStroke
PubMed ID24846872
PubMed Central IDPMC4083192
Grant List / / Medical Research Council / United Kingdom
/ / Department of Health / United Kingdom
P30 DK072488 / DK / NIDDK NIH HHS / United States
Z99 OD999999 / / Intramural NIH HHS / United States
/ / Wellcome Trust / United Kingdom