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Stroke; a journal of cerebral circulation DOI:10.1161/STROKEAHA.114.005208

Effect of Genetic Variants Associated With Plasma Homocysteine Levels on Stroke Risk.

Publication TypeJournal Article
Year of Publication2014
AuthorsCotlarciuc, I, Malik, R, Holliday, EG, Ahmadi, KR, Paré, G, Psaty, BM, Fornage, M, Hasan, N, Rinne, PE, Ikram, MA, Markus, HS, Rosand, J, Mitchell, BD, Kittner, SJ, Meschia, JF, van Meurs, JB, Uitterlinden, AG, Worrall, BB, Dichgans, M, Sharma, P, on behalf of METASTROKE and the International Stroke Genetics, C
JournalStroke; a journal of cerebral circulation
Date Published2014/05/20

Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes.