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PloS one DOI:10.1371/journal.pone.0093772

Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.

Publication TypeJournal Article
Year of Publication2014
AuthorsPearson-Fuhrhop, KM, Dunn, EC, Mortero, S, Devan, WJ, Falcone, GJ, Lee, P, Holmes, AJ, Hollinshead, MO, Roffman, JL, Smoller, JW, Rosand, J, Cramer, SC
JournalPloS one
Volume9
Issue5
Pagese93772
Date Published2014/01/01
Abstract

Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the pathophysiology of depression, evidence linking dopamine-related genes to depression has been mixed. The current study sought to address this knowledge-gap by examining whether the combined effect of dopamine polymorphisms was associated with depressive symptomatology in both healthy individuals and individuals with depression.

URLhttp://dx.plos.org/10.1371/journal.pone.0093772
DOI10.1371/journal.pone.0093772
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24834916?dopt=Abstract