|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Pearson-Fuhrhop, KM, Dunn, EC, Mortero, S, Devan, WJ, Falcone, GJ, Lee, P, Holmes, AJ, Hollinshead, MO, Roffman, JL, Smoller, JW, Rosand, J, Cramer, SC|
Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the pathophysiology of depression, evidence linking dopamine-related genes to depression has been mixed. The current study sought to address this knowledge-gap by examining whether the combined effect of dopamine polymorphisms was associated with depressive symptomatology in both healthy individuals and individuals with depression.