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Circ Cardiovasc Genet DOI:10.1161/CIRCGENETICS.113.000412

Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.

Publication TypeJournal Article
Year of Publication2014
AuthorsSaxena, R, Bjonnes, A, Prescott, J, Dib, P, Natt, P, Lane, J, Lerner, M, Cooper, JA, Ye, Y, Li, KWah, Maubaret, CG, Codd, V, Brackett, D, Mirabello, L, Kraft, P, Dinney, CP, Stowell, D, Peyton, M, Ralhan, S, Wander, GS, Mehra, NK, Salpea, KD, Gu, J, Wu, X, Mangino, M, Hunter, DJ, De Vivo, I, Humphries, SE, Samani, NJ, Spector, TD, Savage, SA, Sanghera, DK
JournalCirc Cardiovasc Genet
Date Published2014 Jun
KeywordsAdult, Aged, Asian Continental Ancestry Group, Casein Kinase II, Cohort Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, India, Leukocytes, Male, Middle Aged, Phosphorylation, Polymorphism, Single Nucleotide, Religion, Telomere, Young Adult

BACKGROUND: Telomere length is a heritable trait, and short telomere length has been associated with multiple chronic diseases. We investigated the relationship of relative leukocyte telomere length with cardiometabolic risk and performed the first genome-wide association study and meta-analysis to identify variants influencing relative telomere length in a population of Sikhs from South Asia.

METHODS AND RESULTS: Our results revealed a significant independent association of shorter relative telomere length with type 2 diabetes mellitus and heart disease. Our discovery genome-wide association study (n=1616) was followed by stage 1 replication of 25 top signals (P

CONCLUSIONS: By identification of a novel signal in telomere pathway genes, our study provides new molecular insight into the underlying mechanism that may regulate telomere length and its association with human aging and cardiometabolic pathophysiology.


Alternate JournalCirc Cardiovasc Genet
PubMed ID24795349
PubMed Central IDPMC4106467
Grant ListRG/08/008/25291 / / British Heart Foundation / United Kingdom
PG08/008 / / British Heart Foundation / United Kingdom
R01 DK082766 / DK / NIDDK NIH HHS / United States
R01DK082766 / DK / NIDDK NIH HHS / United States
K01 TW006087 / TW / FIC NIH HHS / United States