|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Saxena, R, Bjonnes, A, Prescott, J, Dib, P, Natt, P, Lane, J, Lerner, M, Cooper, JA, Ye, Y, Li, KWah, Maubaret, CG, Codd, V, Brackett, D, Mirabello, L, Kraft, P, Dinney, CP, Stowell, D, Peyton, M, Ralhan, S, Wander, GS, Mehra, NK, Salpea, KD, Gu, J, Wu, X, Mangino, M, Hunter, DJ, De Vivo, I, Humphries, SE, Samani, NJ, Spector, TD, Savage, SA, Sanghera, DK|
|Journal||Circ Cardiovasc Genet|
|Date Published||2014 Jun|
|Keywords||Adult, Aged, Asian Continental Ancestry Group, Casein Kinase II, Cohort Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, India, Leukocytes, Male, Middle Aged, Phosphorylation, Polymorphism, Single Nucleotide, Religion, Telomere, Young Adult|
BACKGROUND: Telomere length is a heritable trait, and short telomere length has been associated with multiple chronic diseases. We investigated the relationship of relative leukocyte telomere length with cardiometabolic risk and performed the first genome-wide association study and meta-analysis to identify variants influencing relative telomere length in a population of Sikhs from South Asia.
METHODS AND RESULTS: Our results revealed a significant independent association of shorter relative telomere length with type 2 diabetes mellitus and heart disease. Our discovery genome-wide association study (n=1616) was followed by stage 1 replication of 25 top signals (P
CONCLUSIONS: By identification of a novel signal in telomere pathway genes, our study provides new molecular insight into the underlying mechanism that may regulate telomere length and its association with human aging and cardiometabolic pathophysiology.
|Alternate Journal||Circ Cardiovasc Genet|
|PubMed Central ID||PMC4106467|
|Grant List||RG/08/008/25291 / / British Heart Foundation / United Kingdom |
PG08/008 / / British Heart Foundation / United Kingdom
R01 DK082766 / DK / NIDDK NIH HHS / United States
R01DK082766 / DK / NIDDK NIH HHS / United States
K01 TW006087 / TW / FIC NIH HHS / United States