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Cell Res DOI:10.1038/cr.2014.54

'Lnc'-ing enhancers to MYC regulation.

Publication TypeJournal Article
Year of Publication2014
AuthorsYounger, ST, Rinn, JL
JournalCell Res
Volume24
Issue6
Pages643-4
Date Published2014 Jun
ISSN1748-7838
KeywordsChromatin, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Humans, Proto-Oncogene Proteins c-myc, RNA, Long Noncoding
Abstract

Long noncoding RNAs (lncRNAs) are emerging as important functional components in the establishment of long-range chromosomal interactions. In a recent paper published in Cell Research, Xiang et al. provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L, a colorectal cancer-specific lncRNA, in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.

URLhttp://dx.doi.org/10.1038/cr.2014.54
DOI10.1038/cr.2014.54
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24777251?dopt=Abstract

Alternate JournalCell Res.
PubMed ID24777251
PubMed Central IDPMC4042177