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Front Immunol DOI:10.3389/fimmu.2014.00157

Gut microbiota and the paradox of cancer immunotherapy.

Publication TypeJournal Article
Year of Publication2014
AuthorsPoutahidis, T, Kleinewietfeld, M, Erdman, SE
JournalFront Immunol
Date Published2014

It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.


Alternate JournalFront Immunol
PubMed ID24778636
PubMed Central IDPMC3985000
Grant ListP30 ES002109 / ES / NIEHS NIH HHS / United States
R01 CA108854 / CA / NCI NIH HHS / United States
U01 CA164337 / CA / NCI NIH HHS / United States