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Frontiers in immunology DOI:10.3389/fimmu.2014.00157

Gut Microbiota and the Paradox of Cancer Immunotherapy.

Publication TypeJournal Article
Year of Publication2014
AuthorsPoutahidis, T, Kleinewietfeld, M, Erdman, SE
JournalFrontiers in immunology
Date Published2014/01/01

It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.