Gut microbiota and the paradox of cancer immunotherapy.
Front Immunol
Authors | |
Abstract | It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment. |
Year of Publication | 2014
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Journal | Front Immunol
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Volume | 5
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Pages | 157
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Date Published | 2014
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URL | |
DOI | 10.3389/fimmu.2014.00157
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PubMed ID | 24778636
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PubMed Central ID | PMC3985000
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Links | |
Grant list | P30 ES002109 / ES / NIEHS NIH HHS / United States
R01 CA108854 / CA / NCI NIH HHS / United States
U01 CA164337 / CA / NCI NIH HHS / United States
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