Improved reference genome of Aedes aegypti informs arbovirus vector control.
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Abstract | Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector. |
Year of Publication | 2018
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Journal | Nature
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Volume | 563
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Issue | 7732
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Pages | 501-507
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Date Published | 2018 11
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ISSN | 1476-4687
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DOI | 10.1038/s41586-018-0692-z
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PubMed ID | 30429615
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PubMed Central ID | PMC6421076
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Grant list | U01 HL130010 / HL / NHLBI NIH HHS / United States
UL1 TR000043 / TR / NCATS NIH HHS / United States
F30 DC017658 / DC / NIDCD NIH HHS / United States
R01 AI121211 / AI / NIAID NIH HHS / United States
R35 GM118336 / GM / NIGMS NIH HHS / United States
K22 AI113060 / AI / NIAID NIH HHS / United States
UM1 HG009375 / HG / NHGRI NIH HHS / United States
R01 DC014247 / DC / NIDCD NIH HHS / United States
R01 AI101112 / AI / NIAID NIH HHS / United States
R01 AI123338 / AI / NIAID NIH HHS / United States
DP2 OD008540 / OD / NIH HHS / United States
T32 GM007739 / GM / NIGMS NIH HHS / United States
R21 AI121853 / AI / NIAID NIH HHS / United States
R21 AI123937 / AI / NIAID NIH HHS / United States
U19 AI110818 / AI / NIAID NIH HHS / United States
BB/F021933/1 / Biotechnology and Biological Sciences Research Council / United Kingdom
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