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Immunological reviews DOI:10.1111/imr.12169

Regulatory T cells in autoimmune neuroinflammation.

Publication TypeJournal Article
Year of Publication2014
AuthorsKleinewietfeld, M, Hafler, DA
JournalImmunological reviews
Volume259
Issue1
Pages231-44
Date Published2014/05/01
ISSN0105-2896
Abstract

Regulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4(+) T-helper (Th) cell lineage. These specific subtypes can be discriminated according to phenotype and function. Forkhead box protein 3 (FoxP3)-expressing natural Treg cells (Tregs) and IL-10-producing, T-regulatory type 1 cells (Tr1) are the best-studied types of CD4(+) regulatory T cells in humans and experimental animal models. It was shown that they play a crucial role during autoimmune neuroinflammation. Both cells types seem to be particularly important for multiple sclerosis (MS). Here, we discuss the role of CD4(+) regulatory T cells in autoimmune neuroinflammation with an emphasis on Tregs and Tr1 cells in MS.

URLhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-2896&date=2014&volume=259&spage=231
DOI10.1111/imr.12169
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24712469?dopt=Abstract