You are here

Trends Cell Biol DOI:10.1016/j.tcb.2014.03.003

Regulation of mTORC1 by amino acids.

Publication TypeJournal Article
Year of Publication2014
AuthorsBar-Peled, L, Sabatini, DM
JournalTrends Cell Biol
Date Published2014 Jul
KeywordsAmino Acids, Animals, Humans, Lysosomes, Multiprotein Complexes, Signal Transduction, TOR Serine-Threonine Kinases

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation.


Alternate JournalTrends Cell Biol.
PubMed ID24698685
PubMed Central IDPMC4074565
Grant ListR01 AI047389 / AI / NIAID NIH HHS / United States
R01 CA103866 / CA / NCI NIH HHS / United States
CA103866 / CA / NCI NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
R03 DA034602 / DA / NIDA NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R01 CA129105 / CA / NCI NIH HHS / United States
AI47389 / AI / NIAID NIH HHS / United States