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Nat Rev Genet DOI:10.1038/nrg3664

Genomic insights into tuberculosis.

Publication TypeJournal Article
Year of Publication2014
AuthorsGalagan, JE
JournalNat Rev Genet
Volume15
Issue5
Pages307-20
Date Published2014 May
ISSN1471-0064
KeywordsDrug Resistance, Multiple, Bacterial, Evolution, Molecular, Genome, Bacterial, Genomics, Humans, Molecular Epidemiology, Mycobacterium tuberculosis, Phylogeny, Systems Biology, Tuberculosis
Abstract

Prevalent since pre-history, human tuberculosis - caused by the pathogen Mycobacterium tuberculosis - remains a major source of death worldwide. Moreover, increasing drug resistance poses the threat of disease resurgence. However, the expanding application of genomic techniques is providing new avenues for combating this old foe. Whole-genome sequencing, comparative genomics and systems biology are generating new insights into the origins and ongoing evolution of M. tuberculosis, as well as the molecular basis for its pathogenicity. These have important implications for our perspective of the disease, development of new drugs and vaccines, and treatment of patients using existing therapeutics.

URLhttp://dx.doi.org/10.1038/nrg3664
DOI10.1038/nrg3664
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24662221?dopt=Abstract

Alternate JournalNat. Rev. Genet.
PubMed ID24662221
Grant ListHHSN272200800059C / / PHS HHS / United States