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Nature reviews. Genetics DOI:10.1038/nrg3664

Genomic insights into tuberculosis.

Publication TypeJournal Article
Year of Publication2014
AuthorsGalagan, JE
JournalNature reviews. Genetics
Volume15
Issue5
Pages307-20
Date Published2014/05/01
ISSN1471-0056
Abstract

Prevalent since pre-history, human tuberculosis - caused by the pathogen Mycobacterium tuberculosis - remains a major source of death worldwide. Moreover, increasing drug resistance poses the threat of disease resurgence. However, the expanding application of genomic techniques is providing new avenues for combating this old foe. Whole-genome sequencing, comparative genomics and systems biology are generating new insights into the origins and ongoing evolution of M. tuberculosis, as well as the molecular basis for its pathogenicity. These have important implications for our perspective of the disease, development of new drugs and vaccines, and treatment of patients using existing therapeutics.

URLhttp://dx.doi.org/10.1038/nrg3664
DOI10.1038/nrg3664
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24662221?dopt=Abstract