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Am J Hum Genet DOI:10.1016/j.ajhg.2014.02.012

Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.

Publication TypeJournal Article
Year of Publication2014
AuthorsWoo, D, Falcone, GJ, Devan, WJ, W Brown, M, Biffi, A, Howard, TD, Anderson, CD, H Brouwers, B, Valant, V, Battey, TWK, Radmanesh, F, Raffeld, MR, Baedorf-Kassis, S, Deka, R, Woo, JG, Martin, LJ, Haverbusch, M, Moomaw, CJ, Sun, G, Broderick, JP, Flaherty, ML, Martini, SR, Kleindorfer, DO, Kissela, B, Comeau, ME, Jagiella, JM, Schmidt, H, Freudenberger, P, Pichler, A, Enzinger, C, Hansen, BM, Norrving, B, Jimenez-Conde, J, Giralt-Steinhauer, E, Elosua, R, Cuadrado-Godia, E, Soriano, C, Roquer, J, Kraft, P, Ayres, AM, Schwab, K, McCauley, JL, Pera, J, Urbanik, A, Rost, NS, Goldstein, JN, Viswanathan, A, Stögerer, E-M, Tirschwell, DL, Selim, M, Brown, DL, Silliman, SL, Worrall, BB, Meschia, JF, Kidwell, CS, Montaner, J, Fernandez-Cadenas, I, Delgado, P, Malik, R, Dichgans, M, Greenberg, SM, Rothwell, PM, Lindgren, A, Slowik, A, Schmidt, R, Langefeld, CD, Rosand, J
Corporate AuthorsInternational Stroke Genetics Consortium
JournalAm J Hum Genet
Volume94
Issue4
Pages511-21
Date Published2014 Apr 03
ISSN1537-6605
KeywordsCase-Control Studies, Cerebral Hemorrhage, Chromosomes, Human, Pair 1, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Quantitative Trait Loci
Abstract

Intracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar or nonlobar based on the location of ruptured blood vessels within the brain. These different locations also signal different underlying vascular pathologies. Heritability estimates indicate a substantial genetic contribution to risk of ICH in both locations. We report a genome-wide association study of this condition that meta-analyzed data from six studies that enrolled individuals of European ancestry. Case subjects were ascertained by neurologists blinded to genotype data and classified as lobar or nonlobar based on brain computed tomography. ICH-free control subjects were sampled from ambulatory clinics or random digit dialing. Replication of signals identified in the discovery cohort with p

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0002-9297(14)00070-6
DOI10.1016/j.ajhg.2014.02.012
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24656865?dopt=Abstract

Alternate JournalAm. J. Hum. Genet.
PubMed ID24656865
PubMed Central IDPMC3980413
Grant ListK23 NS059774 / NS / NINDS NIH HHS / United States
5K23NS059774 / NS / NINDS NIH HHS / United States
095626 / / Wellcome Trust / United Kingdom
R01 NS070941 / NS / NINDS NIH HHS / United States
R01 NS030678 / NS / NINDS NIH HHS / United States
R01 NS062675 / NS / NINDS NIH HHS / United States
T32 NS047996 / NS / NINDS NIH HHS / United States
P50NS061343 / NS / NINDS NIH HHS / United States
R01 HL098065 / HL / NHLBI NIH HHS / United States
NS069763 / NS / NINDS NIH HHS / United States
U10 NS077311 / NS / NINDS NIH HHS / United States
R18 HS017690 / HS / AHRQ HHS / United States
U01 NS069763 / NS / NINDS NIH HHS / United States
R01 NS059727 / NS / NINDS NIH HHS / United States
NS30678 / NS / NINDS NIH HHS / United States
NS36695 / NS / NINDS NIH HHS / United States
U01 NS074425 / NS / NINDS NIH HHS / United States
UL1 TR001425 / TR / NCATS NIH HHS / United States
R01NS059727 / NS / NINDS NIH HHS / United States
R01 NS036695 / NS / NINDS NIH HHS / United States
M01 RR000042 / RR / NCRR NIH HHS / United States
/ / Wellcome Trust / United Kingdom