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Cell host & microbe DOI:10.1016/j.chom.2014.02.007

Microbes, Microbiota, and Colon Cancer.

Publication TypeJournal Article
Year of Publication2014
AuthorsSears, CL, Garrett, WS
JournalCell host & microbe
Volume15
Issue3
Pages317-328
Date Published2014/03/12
ISSN1931-3128
Abstract

Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1931-3128(14)00065-1
DOI10.1016/j.chom.2014.02.007
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24629338?dopt=Abstract