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Cell Host Microbe DOI:10.1016/j.chom.2014.02.007

Microbes, microbiota, and colon cancer.

Publication TypeJournal Article
Year of Publication2014
AuthorsSears, CL, Garrett, WS
JournalCell Host Microbe
Volume15
Issue3
Pages317-28
Date Published2014 Mar 12
ISSN1934-6069
KeywordsCarcinogenesis, Colorectal Neoplasms, Gastrointestinal Tract, Humans, Microbiota
Abstract

Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1931-3128(14)00065-1
DOI10.1016/j.chom.2014.02.007
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24629338?dopt=Abstract

Alternate JournalCell Host Microbe
PubMed ID24629338
PubMed Central IDPMC4003880
Grant ListR21CA170492 / CA / NCI NIH HHS / United States
R01 CA179440 / CA / NCI NIH HHS / United States
R01CA154426 / CA / NCI NIH HHS / United States
R01CA179440 / CA / NCI NIH HHS / United States
R01 CA151325 / CA / NCI NIH HHS / United States
R01CA151325 / CA / NCI NIH HHS / United States
R01CA151393 / CA / NCI NIH HHS / United States
R01 CA151393 / CA / NCI NIH HHS / United States
R21 CA170492 / CA / NCI NIH HHS / United States
K08AI078942 / AI / NIAID NIH HHS / United States
K08 AI078942 / AI / NIAID NIH HHS / United States
P30 DK034854 / DK / NIDDK NIH HHS / United States
R01 CA154426 / CA / NCI NIH HHS / United States