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IUBMB Life DOI:10.1002/iub.1366

Prohibitin 2: At a communications crossroads.

Publication TypeJournal Article
Year of Publication2015
AuthorsBavelloni, A, Piazzi, M, Raffini, M, Faenza, I, Blalock, WL
JournalIUBMB Life
Date Published2015 Apr
KeywordsAnimals, Gene Expression, Humans, Protein Binding, Repressor Proteins, Signal Transduction

Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators of pathologies such as cancer, neuromuscular degeneration, and other metabolic diseases. The human genome encodes two PHB proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), which function not only as a heterodimeric complex, but also independently. While many previous reviews have focused on the better characterized prohibitin, PHB1, this review focuses on PHB2 and new data concerning its cellular functions both in complex with PHB1 and independent of PHB1.


Alternate JournalIUBMB Life
PubMed ID25904163