You are here

Cell Stem Cell DOI:10.1016/j.stem.2014.02.008

Dietary and metabolic control of stem cell function in physiology and cancer.

Publication TypeJournal Article
Year of Publication2014
AuthorsMihaylova, MM, Sabatini, DM, Yilmaz, ÖH
JournalCell Stem Cell
Volume14
Issue3
Pages292-305
Date Published2014 Mar 06
ISSN1875-9777
KeywordsAnimals, Cell Transformation, Neoplastic, Diet, Homeostasis, Humans, Neoplasms, Signal Transduction, Stem Cells
Abstract

Organismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alters tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1934-5909(14)00059-9
DOI10.1016/j.stem.2014.02.008
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24607404?dopt=Abstract

Alternate JournalCell Stem Cell
PubMed ID24607404
PubMed Central IDPMC3992244
Grant ListR01 AI047389 / AI / NIAID NIH HHS / United States
R01 CA103866 / CA / NCI NIH HHS / United States
DK043351 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
K99 AG045144 / AG / NIA NIH HHS / United States
AI047389 / AI / NIAID NIH HHS / United States
CA103866 / CA / NCI NIH HHS / United States
AG045144 / AG / NIA NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
R00 AG045144 / AG / NIA NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
CA129105 / CA / NCI NIH HHS / United States
R01 CA129105 / CA / NCI NIH HHS / United States