You are here

The Journal of surgical research DOI:10.1016/j.jss.2014.01.056

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.

Publication TypeJournal Article
Year of Publication2014
AuthorsZhao, T, Li, Y, Liu, B, Halaweish, I, Mazitschek, R, Alam, HB
JournalThe Journal of surgical research
Date Published2014/02/04

Phagocytes, especially monocytes, macrophages, and dendritic cells, play a pivotal role in the innate and adaptive immune responses during sepsis. We have shown that inhibition of histone deacetylase 6 improves survival and increases bacterial clearance in a mouse model of cecal ligation and puncture (CLP). The aim of this study was to determine whether this effect was associated with changes in the number and composition of different blood cell types in the circulation.