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PloS one DOI:10.1371/journal.pone.0089441

Pathway analyses implicate glial cells in schizophrenia.

Publication TypeJournal Article
Year of Publication2014
AuthorsDuncan, LE, Holmans, PA, Lee, PH, O'Dushlaine, CT, Kirby, AW, Smoller, JW, Öngür, D, Cohen, BM
JournalPloS one
Volume9
Issue2
Pagese89441
Date Published2014/01/01
Abstract

The quest to understand the neurobiology of schizophrenia and bipolar disorder is ongoing with multiple lines of evidence indicating abnormalities of glia, mitochondria, and glutamate in both disorders. Despite high heritability estimates of 81% for schizophrenia and 75% for bipolar disorder, compelling links between findings from neurobiological studies, and findings from large-scale genetic analyses, are only beginning to emerge.

URLhttp://dx.plos.org/10.1371/journal.pone.0089441
DOI10.1371/journal.pone.0089441
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24586781?dopt=Abstract