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Arteriosclerosis, thrombosis, and vascular biology DOI:10.1161/ATVBAHA.113.302088

Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.

Publication TypeJournal Article
Year of Publication2014
AuthorsHuang, J, Huffman, JE, Yamkauchi, M, Trompet, S, Asselbergs, FW, Sabater-Lleal, M, Trégouët, DA, Chen, WM, Smith, NL, Kleber, ME, Shin, SY, Becker, DM, Tang, W, Dehghan, A, Johnson, AD, Truong, V, Folkersen, L, Yang, Q, Oudot-Mellkah, T, Buckley, BM, Moore, JH, Williams, FM, Campbell, H, Silbernagel, G, Vitart, V, Rudan, I, Tofler, GH, Navis, GJ, Destefano, A, Wright, AF, Chen, MH, de Craen, AJ, Worrall, BB, Rudnicka, AR, Rumley, A, Bookman, EB, Psaty, BM, Chen, F, Keene, KL, Franco, OH, Böhm, BO, Uitterlinden, AG, Carter, AM, Jukema, JW, Sattar, N, Bis, JC, Ikram, MA, the Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working, G, Sale, MM, McKnight, B, Fornage, M, Ford, I, Taylor, K, Slagboom, PE, McArdle, WL, Hsu, FC, Franco-Cereceda, A, Goodall, AH, Yanek, LR, Furie, KL, Cushman, M, Hofman, A, Witteman, JC, Folsom, AR, Basu, S, Matijevic, N, van Gilst, WH, Wilson, JF, Westendorp, RG, Kathiresan, S, Reilly, MP, the CARDIoGRAM, C, Tracy, RP, Polasek, O, Winkelmann, BR, Grant, PJ, Hillege, HL, Cambien, F, Stott, DJ, Lowe, GD, Spector, TD, Meigs, JB, Marz, W, Eriksson, P, Becker, LC, Morange, PE, Soranzo, N, Williams, SM, Hayward, C, van der Harst, P, Hamsten, A, Lowenstein, CJ, Strachan, DP, O'Donnell, CJ, the CHARGE Consortium Hemostatic Factor Working, G
JournalArteriosclerosis, thrombosis, and vascular biology
Date Published2014/02/27

Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases. We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA.