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Am J Hum Genet DOI:10.1016/j.ajhg.2013.12.016

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Publication TypeJournal Article
Year of Publication2014
AuthorsTragante, V, Barnes, MR, Ganesh, SK, Lanktree, MB, Guo, W, Franceschini, N, Smith, EN, Johnson, T, Holmes, MV, Padmanabhan, S, Karczewski, KJ, Almoguera, B, Barnard, J, Baumert, J, Chang, Y-PChristy, Elbers, CC, Farrall, M, Fischer, ME, Gaunt, TR, Gho, JMIH, Gieger, C, Goel, A, Gong, Y, Isaacs, A, Kleber, ME, Leach, IMateo, McDonough, CW, Meijs, MFL, Melander, O, Nelson, CP, Nolte, IM, Pankratz, N, Price, TS, Shaffer, J, Shah, S, Tomaszewski, M, van der Most, PJ, van Iperen, EPA, Vonk, JM, Witkowska, K, Wong, COL, Zhang, L, Beitelshees, AL, Berenson, GS, Bhatt, DL, Brown, M, Burt, A, Cooper-DeHoff, RM, Connell, JM, Cruickshanks, KJ, Curtis, SP, Davey-Smith, G, Delles, C, Gansevoort, RT, Guo, X, Haiqing, S, Hastie, CE, Hofker, MH, G Hovingh, K, Kim, DS, Kirkland, SA, Klein, BE, Klein, R, Li, YR, Maiwald, S, Newton-Cheh, C, O'Brien, ET, N Onland-Moret, C, Palmas, W, Parsa, A, Penninx, BW, Pettinger, M, Vasan, RS, Ranchalis, JE, Ridker, PM, Rose, LM, Sever, P, Shimbo, D, Steele, L, Stolk, RP, Thorand, B, Trip, MD, van Duijn, CM, W Verschuren, M, Wijmenga, C, Wyatt, S, J Young, H, Zwinderman, AH, Bezzina, CR, Boerwinkle, E, Casas, JP, Caulfield, MJ, Chakravarti, A, Chasman, DI, Davidson, KW, Doevendans, PA, Dominiczak, AF, FitzGerald, GA, Gums, JG, Fornage, M, Hakonarson, H, Halder, I, Hillege, HL, Illig, T, Jarvik, GP, Johnson, JA, Kastelein, JJP, Koenig, W, Kumari, M, März, W, Murray, SS, O'Connell, JR, Oldehinkel, AJ, Pankow, JS, Rader, DJ, Redline, S, Reilly, MP, Schadt, EE, Kottke-Marchant, K, Snieder, H, Snyder, M, Stanton, AV, Tobin, MD, Uitterlinden, AG, van der Harst, P, van der Schouw, YT, Samani, NJ, Watkins, H, Johnson, AD, Reiner, AP, Zhu, X, de Bakker, PIW, Levy, D, Asselbergs, FW, Munroe, PB, Keating, BJ
JournalAm J Hum Genet
Volume94
Issue3
Pages349-60
Date Published2014 Mar 06
ISSN1537-6605
KeywordsArterial Pressure, Blood Pressure, Computational Biology, Diastole, Europe, European Continental Ancestry Group, Genetic Loci, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Phenotype, Polymorphism, Single Nucleotide, Quality Control, Quantitative Trait Loci, Risk Factors, Systole
Abstract

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0002-9297(13)00613-7
DOI10.1016/j.ajhg.2013.12.016
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24560520?dopt=Abstract

Alternate JournalAm. J. Hum. Genet.
PubMed ID24560520
PubMed Central IDPMC3951943
Grant ListSP/08/002/24118 / / British Heart Foundation / United Kingdom
G9521010 / / Medical Research Council / United Kingdom
PG/09/022/26739 / / British Heart Foundation / United Kingdom
G0802432 / / Medical Research Council / United Kingdom
FS/11/35/28871 / / British Heart Foundation / United Kingdom
UL1 TR000064 / TR / NCATS NIH HHS / United States
U01 GM074492 / GM / NIGMS NIH HHS / United States
R37 AG011099 / AG / NIA NIH HHS / United States
R01 AG021917 / AG / NIA NIH HHS / United States
FS/12/33/29561 / / British Heart Foundation / United Kingdom
R01 AG016592 / AG / NIA NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
PG/07/085/23349 / / British Heart Foundation / United Kingdom
R01 HL074730 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
FS/14/12/30540 / / British Heart Foundation / United Kingdom
FS/12/8/29377 / / British Heart Foundation / United Kingdom
P30 DK072488 / DK / NIDDK NIH HHS / United States
MC_UU_12013/1 / / Medical Research Council / United Kingdom
090532 / / Wellcome Trust / United Kingdom
G0902313 / / Medical Research Council / United Kingdom
MR/K006584/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
MC_UU_12013/8 / / Medical Research Council / United Kingdom