Recent discoveries and applications involving small-molecule microarrays.
Curr Opin Chem Biol
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Abstract | High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications. |
Year of Publication | 2014
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Journal | Curr Opin Chem Biol
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Volume | 18
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Pages | 21-8
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Date Published | 2014 Feb
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ISSN | 1879-0402
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URL | |
DOI | 10.1016/j.cbpa.2013.09.020
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PubMed ID | 24534749
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PubMed Central ID | PMC3943826
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Grant list | R01 CA160860 / CA / NCI NIH HHS / United States
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