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Current opinion in chemical biology DOI:10.1016/j.cbpa.2013.09.020

Recent discoveries and applications involving small-molecule microarrays.

Publication TypeJournal Article
Year of Publication2014
AuthorsHong, JA, Neel, DV, Wassaf, D, Caballero, F, Koehler, AN
JournalCurrent opinion in chemical biology
Volume18C
Pages21-28
Date Published2014/02/01
ISSN1367-5931
Abstract

High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1367-5931(13)00196-8
DOI10.1016/j.cbpa.2013.09.020
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24534749?dopt=Abstract