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Curr Opin Chem Biol DOI:10.1016/j.cbpa.2013.09.020

Recent discoveries and applications involving small-molecule microarrays.

Publication TypeJournal Article
Year of Publication2014
AuthorsHong, JA, Neel, DV, Wassaf, D, Caballero, F, Koehler, AN
JournalCurr Opin Chem Biol
Date Published2014 Feb
KeywordsBiomarkers, Cell Survival, Humans, Microarray Analysis, Protein Binding, Proteins, Small Molecule Libraries

High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications.


Alternate JournalCurr Opin Chem Biol
PubMed ID24534749
PubMed Central IDPMC3943826
Grant ListR01 CA160860 / CA / NCI NIH HHS / United States