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Biological psychiatry DOI:10.1016/j.biopsych.2013.12.018

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated with Panic Disorder and Amygdala Structure and Function.

Publication TypeJournal Article
Year of Publication2014
AuthorsSmoller, JW, Gallagher, PJ, Duncan, LE, McGrath, LM, Haddad, SA, Holmes, AJ, Wolf, AB, Hilker, S, Block, SR, Weill, S, Young, S, Choi, EY, Rosenbaum, JF, Biederman, J, Faraone, SV, Roffman, JL, Manfro, GG, Blaya, C, Hirshfeld-Becker, DR, Stein, MB, Van Ameringen, M, Tolin, DF, Otto, MW, Pollack, MH, Simon, NM, Buckner, RL, Ongür, D, Cohen, BM
JournalBiological psychiatry
Date Published2014/01/18

Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide-mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function.