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Nature reviews. Drug discovery DOI:10.1038/nrd4231

Targeting the pancreatic β-cell to treat diabetes.

Publication TypeJournal Article
Year of Publication2014
AuthorsVetere, A, Choudhary, A, Burns, SM, Wagner, BK
JournalNature reviews. Drug discovery
Date Published2014/02/14

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect over 500 million people by 2030. However, this growing burden of disease has not been met with a comparable expansion in therapeutic options. The appreciation of the pancreatic β-cell as a central player in the pathogenesis of both type 1 and type 2 diabetes has renewed focus on ways to improve glucose homeostasis by preserving, expanding and improving the function of this key cell type. Here, we provide an overview of the latest developments in this field, with an emphasis on the most promising strategies identified to date for treating diabetes by targeting the β-cell.