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J Cereb Blood Flow Metab DOI:10.1038/jcbfm.2014.27

Zebrafish models of cerebrovascular disease.

Publication TypeJournal Article
Year of Publication2014
AuthorsWalcott, BP, Peterson, RT
JournalJ Cereb Blood Flow Metab
Volume34
Issue4
Pages571-7
Date Published2014 Apr
ISSN1559-7016
KeywordsAnimals, Cerebrovascular Disorders, Disease Models, Animal, Drug Discovery, Zebrafish
Abstract

Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a heterogeneous group of disease processes, the ultimate final pathologic insult in humans is defined as a stroke, or damage to brain parenchyma. In the case of ischemic stroke, blood fails to reach its target destination whereas in hemorrhagic stroke, extravasation of blood occurs outside of the blood vessel lumen, resulting in direct damage to brain parenchyma. As these acute events can be neurologically devastating, if not fatal, development of novel therapeutics are urgently needed. The zebrafish (Danio rerio) is an attractive model for the study of cerebrovascular disease because of its morphological and physiological similarity to human cerebral vasculature, its ability to be genetically manipulated, and its fecundity allowing for large-scale, phenotype-based screens.

URLhttp://dx.doi.org/10.1038/jcbfm.2014.27
DOI10.1038/jcbfm.2014.27
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24517974?dopt=Abstract

Alternate JournalJ. Cereb. Blood Flow Metab.
PubMed ID24517974
PubMed Central IDPMC3982096