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Nat Rev Neurosci DOI:10.1038/nrn3621

DSM-5 and RDoC: progress in psychiatry research?

Publication TypeJournal Article
Year of Publication2013
AuthorsCasey, BJ, Craddock, N, Cuthbert, BN, Hyman, SE, Lee, FS, Ressler, KJ
JournalNat Rev Neurosci
Date Published2013 Nov
KeywordsBiomedical Research, Brain, Diagnostic and Statistical Manual of Mental Disorders, Humans, Mental Disorders, National Institute of Mental Health (U.S.), Neuropsychological Tests, Psychiatry, United States

Neuroscience studies into psychiatric disorders generally rely on disease definitions that are based on the influential Diagnostic and Statistical Manual of Mental Disorders (DSM), the fifth edition of which (DSM-5) was released earlier this year. Designed as a purely diagnostic tool, the DSM considers different disorders as distinct entities. However, boundaries between disorders are often not as strict as the DSM suggests. To provide an alternative framework for research into psychiatric disorders, the US National Institute of Mental Health (NIMH) has recently introduced its Research Domain Criteria (RDoC) project. In the RDoC, five 'domains' each reflect a brain system in which functioning is impaired, to different degrees, in different psychiatric conditions. Nature Reviews Neuroscience asked six leading investigators for their thoughts on how DSM-5 and the RDoC will influence neuroscience research into psychiatric disorders.


Alternate JournalNat. Rev. Neurosci.
PubMed ID24135697
PubMed Central IDPMC4372467
Grant ListP50 MH079513 / MH / NIMH NIH HHS / United States
R01 NS052819 / NS / NINDS NIH HHS / United States